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The Effect of Liraglutide on Left Ventricular Function in Stable Chronic Heart Failure (LIVE) trial in 2016 marked one of the first assessments of a GLP-1 analog for the treatment HFrEF, specifically examining the effects of liraglutide on left ventricular ejection fraction in patients with chronic, stable HFrEF [51]

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If intact peptide concentrations in portal blood are below threshold despite high oral dosing, enteric-coated formulations or co-administration with protease inhibitors may be required

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Dihexa is not approved by any regulatory authority for human use